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REVIEW ARTICLE
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Antibiotic susceptibility of endodontic pathogens: A systematic review


1 Department of Conservative Dentistry and Endodontics, Sree Mookambika Institute of Dental Sciences, Kulasekharam, Kanyakumari, Tamil Nadu, India
2 Department of Conservative Dentistry and Endodontics, KVG Dental College and Hospital, Sullia, Dakshina Kannada, Karnataka, India

Correspondence Address:
RV Vineet,
Department of Conservative Dentistry and Endodontics, Sree Mookambika Institute of Dental Sciences, Kulasekharam, Kanyakumari, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None

The purpose of this systematic review was to determine, the susceptibility of endodontic pathogens to commonly prescribed antibiotics. The MEDLINE, Embase, Cochrane, and PubMed databases were searched. In addition, the bibliographies of all relevant articles and textbooks were manually searched. Based on inclusion and exclusion criteria, two reviewers independently selected the relevant articles. Due to the variety of methodologies and different techniques used to measure antibiotic sensitivity, it was not possible to standardize the research data and to apply a meta-analysis. Fifteen articles were identified that met the inclusion criteria. Most of the studies showed a high susceptibility for amoxicillin-clavulanic acid combination against root canal pathogens and metronidazole showed the least susceptibility. In the case of root filled tooth moxifloxacin and levofloxacin was found to be highly effective. The results of the systematic review confirmed that more evidence-based research in this area is needed. With the limited information currently available, the best current available clinical evidence suggests that microorganisms present in a biofilm community are more resistant to antibiotics, and is becoming a major dental and medical problem.


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    -  Vineet R V
    -  Nayak M
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