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Granular cell tumor at commissure of lip

 Department of Oral Pathology and Microbiology, Vasantdada Patil Dental College and Hospital, Sangli, Maharashtra, India

Correspondence Address:
Priya Shirish Joshi,
Flat No. B-3, Avani Appartment, Datta Nagar, 80 Feet Road, Vishrambag, Sangli - 416 416, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0976-6944.187429

Granular cell tumor (GCT) is an infrequent benign neoplasm which has a neural crest cell origin. Although it is rare in the oral cavity, the most frequent site is tongue followed by the floor of mouth and buccal mucosa. The tumor generally occurs in middle-aged female patient and appears as solitary nodular mass covered by intact overlying mucosa with a yellowish surface coloration resembling traumatic fibroma. This article discusses a rare case report of GCT affecting the right commissure of the lip in a 45-year-old male patient. The diagnosis was confirmed on histopathological examination, which revealed tumor cells with eosinophilic, periodic acid-Schiff positive fine granules and was strongly positive for S-100 protein. The article also highlights the associated diagnostic difficulties and significance of immunohistochemistry in diagnosis.

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