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ORIGINAL ARTICLE
Year : 2016  |  Volume : 7  |  Issue : 2  |  Page : 79-82

Salivary tumor necrosis factor alpha and interleukin 6 levels in oral lichen planus patients


1 Department of Oral Medicine, Faculty of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Periodontology and Implant, Faculty of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Department of Immunology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Correspondence Address:
Hojatollah Yousefimanesh
Department of Periodontology and Implant, Faculty of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-6944.194206

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Background: Oral lichen planus (OLP) is an inflammatory disease, and its etiology remains unknown, but there is much evidence that implies the existence of an immunological background. Aims: The salivary levels of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) as representatives of T-helper 1, 2 cells in OLP are compared to healthy individuals. Methods: This case-control study contains 60 patients with OLP and 30 healthy individuals. Patients were selected from those referred to the Department of Oral Medicine of Ahvaz Dentistry. After explaining the study whole saliva was collected. The salivary levels of TNF-α and IL-6 were measured using ELISA test. Statistical Analysis: t-test and Kruskal-Wallis test were used for statistical analysis. Results: The salivary levels of TNF-α and IL-6 in the group with OLP were significantly higher than the healthy group. The average concentrations of TNF-α and IL-6 were in the erosive/atrophic group (0.23 ± 0.08, 0.46 ± 0.02 Pg/ml respectively). The salivary levels of TNF-α and IL-6 in the erosive/atrophic group were significantly higher than the healthy and the reticular groups. Conclusions: The salivary levels of TNF-α and IL-6 were significantly increased in the group with OLP.


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